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Determining Protein Structure for Drug Design
State: New York

X-ray Optical systems, Inc. (XOS) has designed and built a protein crystal structure analyzer based on a convergent-beam X-ray diffraction technique.  This technique is capable of analyzing extremely small crystals on the order of a few thousandths of a millimeter. The analyzer is a bench-top system that uses a high-intensity, convergent X-ray beam for fast screening of small protein crystals. This technique is very rapid and more cost-effective than the large synchrotron radiation-based systems that are used currently. The company is commercializing the protein crystal analyzer.  This can be incorporated into existing OEM X-ray analysis systems, which are routinely used by academic and government research laboratories, as well as the pharmaceutical industry. The technology has significant potential for reducing the time and cost of developing new proteins for drug manufacturers, thereby accelerating the development of new drug therapies.


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NSF funding for this project ended in 2008. At this time the site has been archived.